CYTH4, cytohesin 4

CYTH4, cytohesin 4

• This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

• Gene Synonyms (cytohesin-4, PH, SEC7 and coiled-coil domain-containing protein 4, pleckstrin homology, Sec7 and coiled/coil domains 4, CYT4, DJ63G5.1, PSCD4, cytohesin-4,)
• NCBI Gene ID: 27128
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UIA0
  UNIPROT ID#>>B4E2V8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytohesin 4 interacts with:

• angiomotin like 2
  cancer/testis antigen 1A
  chibby family member 2
  coiled-coil domain containing 120
  coiled-coil domain containing 197
  hook microtubule tethering protein 2
  keratin 40
  synaptonemal complex central element protein 1 like
  tripartite motif containing 54
  USH1 protein network component harmonin binding protein 1

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