TJP3, tight junction protein 3

TJP3, tight junction protein 3

• The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

• Gene Synonyms (tight junction protein ZO-3, tight junction protein 3 (zona occludens 3), zona occludens protein 3, zonula occludens protein 3, ZO-3, ZO3,)
• NCBI Gene ID: 27134
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95049
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tight junction protein 3 interacts with:

• occludin
  ribosomal protein L35
  ring finger protein 138

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.