- Gene Overview
- Interaction Network
- Sequence Verification
DPH3, diphthamide biosynthesis 3
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This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
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Gene Synonyms (DPH3 homolog, CSL-type zinc finger-containing protein 2, DPH3 homolog (KTI11, S. cerevisiae), DPH3, KTI11 homolog, DPH3A, KTI11 homolog A, Del-GEF interacting protein, deafness locus putative guanine nucleotide exchange factor interacting protein 1, delGEF-interacting protein 1, diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1, zinc finger, CSL domain containing 2, zinc finger, CSL-type containing 2, DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2,)
- NCBI Gene ID:
285381
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>A0A024R2P5
UNIPROT ID#>>Q96FX2
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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diphthamide biosynthesis 3 interacts with:
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