- Gene Overview
- Interaction Network
- Sequence Verification
NSMCE2, NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
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This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
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Gene Synonyms (E3 SUMO-protein ligase NSE2, E3 SUMO-protein transferase NSE2, NSMCE2/PVT1 fusion, PVT1/NSMCE2 fusion, methyl methanesulfonate sensitivity gene 21, non-SMC element 2, MMS21 homolog, non-structural maintenance of chromosomes element 2 homolog, zinc finger, MIZ-type containing 7, C8orf36, MMS21, NSE2, ZMIZ7,)
- NCBI Gene ID:
286053
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>E5RFJ1
UNIPROT ID#>>A0A024R9J6
UNIPROT ID#>>Q96MF7
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase interacts with:
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