PILRB, paired immunoglobin like type 2 receptor beta

PILRB, paired immunoglobin like type 2 receptor beta

• The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

• Gene Synonyms (paired immunoglobulin-like type 2 receptor beta, activating receptor PILR-beta, activating receptor PILRbeta, cell surface receptor FDFACT, cell surface receptor FDFACT1, cell surface receptor FDFACT2, paired immunoglobin-like receptor beta, paired immunoglobulin-like receptor beta, FDFACT1, FDFACT2,)
• NCBI Gene ID: 29990
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKJ0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

paired immunoglobin like type 2 receptor beta interacts with:

• paired immunoglobin like type 2 receptor alpha
  SAM domain, SH3 domain and nuclear localization signals 1

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