ADGRE2, adhesion G protein-coupled receptor E2

ADGRE2, adhesion G protein-coupled receptor E2

• This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

• Gene Synonyms (adhesion G protein-coupled receptor E2, CD97 antigen, EGF-like module-containing mucin-like hormone receptor-like 2, Leukocyte antigen CD97, egf-like module containing, mucin-like, hormone receptor-like 2, CD312, CD97, EMR2, VBU,)
• NCBI Gene ID: 30817
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHX3
  UNIPROT ID#>>A0JNV7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adhesion G protein-coupled receptor E2 interacts with:

• cAMP responsive element binding protein 3 like 1
  coiled-coil domain containing 107
  dynein cytoplasmic 1 light intermediate chain 1
  ELOVL fatty acid elongase 7
  family with sequence similarity 209 member A
  hydroxysteroid 17-beta dehydrogenase 13
  major facilitator superfamily domain containing 5
  membrane magnesium transporter 1
  mitochondrial transcription termination factor 3
  secretion associated Ras related GTPase 1A
  solute carrier family 7 member 14
  TLC domain containing 4
  transmembrane protein 80

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.