KCNA3, potassium voltage-gated channel subfamily A member 3

KCNA3, potassium voltage-gated channel subfamily A member 3

• Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3, potassium channel 3, potassium channel, voltage gated shaker related subfamily A, member 3, potassium voltage-gated channel, shaker-related subfamily, member 3, type n potassium channel, voltage-gated K(+) channel HuKIII, voltage-gated potassium channel protein Kv1.3, voltage-gated potassium channel subunit Kv1.3,)
• NCBI Gene ID: 3738
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22001
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium voltage-gated channel subfamily A member 3 interacts with:

• dolichol kinase
  NEDD4 like E3 ubiquitin protein ligase
  neuropeptide Y receptor Y4
  neurotrophic receptor tyrosine kinase 2
  potassium voltage-gated channel subfamily A member 4
  potassium voltage-gated channel subfamily A member 5
  potassium voltage-gated channel subfamily A member 6
  potassium voltage-gated channel subfamily E regulatory subunit 4
  protein tyrosine phosphatase 4A3
  SEC24 homolog B, COPII coat complex component
  SHC adaptor protein 3
  transferrin receptor
  upstream binding transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.