KIR3DL2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

KIR3DL2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

• Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

• Gene Synonyms (3DL2, CD158K, KIR-3DL2, NKAT-4, NKAT4, NKAT4B, p140, killer cell immunoglobulin-like receptor 3DL2, CD158 antigen-like family member K, KIR antigen 3DL2, MHC class I NK cell receptor, killer Ig receptor, killer cell immunoglobulin-like receptor 2DL2, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2, killer-cell immunoglobulin-like receptor, natural killer-associated transcript 4, p70 NK receptor CL-5, p70 killer cell inhibitory receptor, p70 natural killer cell receptor clone CL-5,)
• NCBI Gene ID: 3812
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NHI6
  UNIPROT ID#>>P43630
  UNIPROT ID#>>A0A0U1WNF3
  UNIPROT ID#>>Q8NHK6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 interacts with:

• ATR interacting protein
  CDGSH iron sulfur domain 2
  family with sequence similarity 114 member A2
  family with sequence similarity 172 member A
  F-box protein 38
  glomulin, FKBP associated protein
  LDL receptor related protein 12
  methyltransferase like 15
  PDZ and LIM domain 4
  plexin A2
  potassium channel tetramerization domain containing 10
  solute carrier family 27 member 3
  suppression of tumorigenicity 7 like
  transmembrane protein 132A
  transmembrane protein 214
  tripartite motif containing 13
  UFM1 specific peptidase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.