SMAD6, SMAD family member 6

SMAD6, SMAD family member 6

• The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]

• Gene Synonyms (AOVD2, HsT17432, MADH6, MADH7, mothers against decapentaplegic homolog 6, MAD homolog 6, SMAD, mothers against DPP homolog 6, mothers against decapentaplegic, drosophila, homolog of, 6,)
• NCBI Gene ID: 4091
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43541
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SMAD family member 6 interacts with:

• actin related protein 1B
  BMP and activin membrane bound inhibitor
  BPI fold containing family A member 1
  cullin 2
  itchy E3 ubiquitin protein ligase
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase kinase kinase 7
  MYD88 innate immune signal transduction adaptor
  NEDD4 E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  nuclear autoantigenic sperm protein
  pellino E3 ubiquitin protein ligase 1
  polymeric immunoglobulin receptor
  protein inhibitor of activated STAT 3
  protein inhibitor of activated STAT 4
  ribosomal protein S6 kinase A5
  ring finger protein 111
  serine/threonine kinase receptor associated protein
  SMAD family member 7
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  STAM binding protein
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TNF alpha induced protein 3
  transducer of ERBB2, 1
  transforming growth factor beta receptor 1
  TSC22 domain family member 1
  ubiquitin conjugating enzyme E2 O
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 15
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger E-box binding homeobox 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.