MBD1, methyl-CpG binding domain protein 1

MBD1, methyl-CpG binding domain protein 1

• The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

• Gene Synonyms (CXXC3, PCM1, RFT, methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, methyl-CpG binding domain protein 1 isoform PCM1, protein containing methyl-CpG-binding domain 1, the regulator of fibroblast growth factor 2 (FGF-2) transcription,)
• NCBI Gene ID: 4152
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UIS9
  UNIPROT ID#>>A8K654
  UNIPROT ID#>>B4DUR3
  UNIPROT ID#>>B4DI41
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methyl-CpG binding domain protein 1 interacts with:

• 2'-5'-oligoadenylate synthetase like
  activating transcription factor 7 interacting protein
  activating transcription factor 7 interacting protein 2
  ataxin 1 like
  chromatin assembly factor 1 subunit A
  chromobox 4
  chromobox 5
  cyclic GMP-AMP synthase
  H4 clustered histone 1
  histone deacetylase 3
  homeodomain interacting protein kinase 3
  kinesin family member 20A
  kinesin family member 2C
  minichromosome maintenance complex component 2
  Mov10 RISC complex RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  nuclear RNA export factor 1
  pleckstrin homology domain containing A4
  PML-RARA regulated adaptor molecule 1
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 1
  ring finger protein 2
  ring finger protein 2
  serine hydroxymethyltransferase 2
  signal transducer and activator of transcription 1
  Sp1 transcription factor
  suppressor of variegation 3-9 homolog 1
  teneurin transmembrane protein 1
  zinc finger protein 512B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.