EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4

EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4

• This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

• Gene Synonyms (GCN2, PVOD2, eIF-2-alpha kinase GCN2, GCN2 eIF2alpha kinase, GCN2-like protein, general control nonderepressible 2,)
• NCBI Gene ID: 440275
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P2K8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 2 alpha kinase 4 interacts with:

• PALM2 and AKAP2 fusion

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