MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

• This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (MSR, cblE, methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing), aqCbl reductase, aquacobalamin reductase, methionine synthase reductase, mitochondrial,)
• NCBI Gene ID: 4552
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBK8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

5-methyltetrahydrofolate-homocysteine methyltransferase reductase interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  centromere protein E
  cyclin-dependent kinase 13
  germ cell-less 1, spermatogenesis associated
  glycogen synthase kinase 3 beta
  H2A clustered histone 11
  metabolism of cobalamin associated B
  phosphatase and tensin homolog
  spermine synthase
  translin associated factor X
  ubiquitin like modifier activating enzyme 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.