NAGLU, N-acetyl-alpha-glucosaminidase

NAGLU, N-acetyl-alpha-glucosaminidase

• This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CMT2V, MPS-IIIB, MPS3B, NAG, UFHSD, alpha-N-acetylglucosaminidase, N-acetylglucosaminidase, alpha, testicular tissue protein Li 18,)
• NCBI Gene ID: 4669
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJE4
  UNIPROT ID#>>P54802
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

N-acetyl-alpha-glucosaminidase interacts with:

• deoxyribonuclease 2 beta
  dual specificity phosphatase 13
  F-box protein 6
  insulin like 5
  interferon epsilon
  lipase H
  LY6/PLAUR domain containing 4
  lysozyme like 1
  lysozyme like 2
  N-acylethanolamine acid amidase
  oxysterol binding protein like 5
  plasminogen activator, urokinase receptor
  proteoglycan 3, pro eosinophil major basic protein 2
  ring finger protein 123
  sialic acid acetylesterase
  signaling lymphocytic activation molecule family member 1
  sushi domain containing 4
  tafazzin
  transmembrane p24 trafficking protein 10
  transmembrane p24 trafficking protein 4
  transmembrane p24 trafficking protein 9

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.