NDUFA1, NADH:ubiquinone oxidoreductase subunit A1

NDUFA1, NADH:ubiquinone oxidoreductase subunit A1

• The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CI-MWFE, MC1DN12, MWFE, ZNF183, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa, NADH-ubiquinone oxidoreductase MWFE subunit, NADH:ubiquinone oxidoreductase (complex 1), complex I MWFE subunit, type I dehydrogenase,)
• NCBI Gene ID: 4694
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IBB5
  UNIPROT ID#>>O15239
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NADH:ubiquinone oxidoreductase subunit A1 interacts with:

• NADH:ubiquinone oxidoreductase subunit A8
  NADH:ubiquinone oxidoreductase subunit S6
  torsin 1A interacting protein 2
  tripartite motif containing 55
  tripartite motif containing 63

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.