TXNDC12, thioredoxin domain containing 12

TXNDC12, thioredoxin domain containing 12

• This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

• Gene Synonyms (thioredoxin domain-containing protein 12, ER protein 18, ER protein 19, anterior gradient homolog 1, endoplasmic reticulum protein ERp19, endoplasmic reticulum resident protein 18, endoplasmic reticulum resident protein 19, endoplasmic reticulum thioredoxin superfamily member, 18 kDa, protein disulfide isomerase family A, member 16, thioredoxin domain containing 12 (endoplasmic reticulum), thioredoxin-like protein p19, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19,)
• NCBI Gene ID: 51060
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95881
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin domain containing 12 interacts with:

• abhydrolase domain containing 10, depalmitoylase
  abhydrolase domain containing 11
  chromosome 1 open reading frame 198
  cytochrome c oxidase assembly factor 4 homolog
  FKBP prolyl isomerase 7
  glutaredoxin 5
  GTPase, IMAP family member 8
  methionine sulfoxide reductase B3
  mitotic spindle organizing protein 2A
  mitotic spindle organizing protein 2B
  myotrophin
  PIH1 domain containing 1
  SET binding factor 2
  small glutamine rich tetratricopeptide repeat containing beta
  taxilin alpha
  TM2 domain containing 3
  TNFAIP3 interacting protein 2
  TP53 regulated inhibitor of apoptosis 1
  tubulin gamma complex associated protein 5
  tubulin gamma complex associated protein 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.