IRAK4, interleukin 1 receptor associated kinase 4

IRAK4, interleukin 1 receptor associated kinase 4

• This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

• Gene Synonyms (interleukin-1 receptor-associated kinase 4, renal carcinoma antigen NY-REN-64, IMD67, IPD1, IRAK-4, NY-REN-64, REN64,)
• NCBI Gene ID: 51135
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E359
  UNIPROT ID#>>Q9NWZ3
  UNIPROT ID#>>B2RAP9
  UNIPROT ID#>>Q69FE3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 1 receptor associated kinase 4 interacts with:

• pellino E3 ubiquitin protein ligase 1
  pellino E3 ubiquitin protein ligase family member 2
  pellino E3 ubiquitin protein ligase family member 3
  TIR domain containing adaptor protein
  toll like receptor adaptor molecule 2
  tripartite motif containing 7
  V-set and immunoglobulin domain containing 8
  zinc finger protein 597

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.