AADAT, aminoadipate aminotransferase

AADAT, aminoadipate aminotransferase

• This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

• Gene Synonyms (kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, KAT/AadAT, L kynurenine/alpha aminoadipate aminotransferase, alpha-aminoadipate aminotransferase, kynurenine aminotransferase II, kynurenine--oxoglutarate aminotransferase II, kynurenine--oxoglutarate transaminase 2, kynurenine--oxoglutarate transaminase II, KAT2, KATII, KYAT2,)
• NCBI Gene ID: 51166
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N5Z0
  UNIPROT ID#>>Q4W5N8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aminoadipate aminotransferase interacts with:

• coiled-coil-helix-coiled-coil-helix domain containing 4
  kynurenine aminotransferase 3
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  sperm acrosome associated 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.