LEF1, lymphoid enhancer binding factor 1

LEF1, lymphoid enhancer binding factor 1

• This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha, LEF-1, TCF10, TCF1ALPHA, TCF7L3,)
• NCBI Gene ID: 51176
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJU2
  UNIPROT ID#>>A0A024RDI7
  UNIPROT ID#>>Q659G9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lymphoid enhancer binding factor 1 interacts with:

• ALX homeobox 4
  dishevelled binding antagonist of beta catenin 1
  egl-9 family hypoxia inducible factor 3
  lysine methyltransferase 5A
  nemo like kinase
  protein arginine methyltransferase 6
  protein inhibitor of activated STAT 4
  ring finger protein 138
  TNFAIP3 interacting protein 2
  zinc finger and BTB domain containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.