DPH5, diphthamide biosynthesis 5

DPH5, diphthamide biosynthesis 5

• This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (diphthine methyl ester synthase, DPH5 homolog, diphthamide biosynthesis methyltransferase, diphthine synthase, protein x 0011, AD-018, CGI-30, HSPC143, NPD015,)
• NCBI Gene ID: 51611
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KWP1
  UNIPROT ID#>>Q9H2P9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

diphthamide biosynthesis 5 interacts with:

• leucine rich repeat kinase 2
  MYG1 exonuclease
  parvin alpha

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