- Gene Overview
- Interaction Network
- Sequence Verification
ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
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The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
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Gene Synonyms (ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, autotaxin-t, extracellular lysophospholipase D, phosphodiesterase I/nucleotide pyrophosphatase 2, plasma lysophospholipase D, ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2,)
- NCBI Gene ID:
5168
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>E7EUF1
UNIPROT ID#>>Q13822
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
ectonucleotide pyrophosphatase/phosphodiesterase 2 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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