- Gene Overview
- Interaction Network
- Sequence Verification
PI3, peptidase inhibitor 3
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This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
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Gene Synonyms (elafin, PI-3, WAP four-disulfide core domain 14, WAP four-disulfide core domain protein 14, elastase-specific inhibitor, peptidase inhibitor 3, skin-derived, pre-elafin, protease inhibitor 3, skin-derived (SKALP), protease inhibitor WAP3, skin-derived antileukoproteinase, trappin-2, ESI, SKALP, WAP3, WFDC14, cementoin,)
- NCBI Gene ID:
5266
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P19957
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
peptidase inhibitor 3 interacts with:
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this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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