SERPINB8, serpin family B member 8

SERPINB8, serpin family B member 8

• The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]

• Gene Synonyms (serpin B8, cytoplasmic antiproteinase 2, peptidase inhibitor 8, protease inhibitor 8 (ovalbumin type), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8, serpin peptidase inhibitor, clade B (ovalbumin), member 8, C18orf53, CAP2, PI-8, PI8, PSS5,)
• NCBI Gene ID: 5271
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A1B0GU38
  UNIPROT ID#>>P50452
  UNIPROT ID#>>A0A024R2B1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serpin family B member 8 interacts with:

• acidic residue methyltransferase 1
  cilia and flagella associated protein 298
  cyclase associated actin cytoskeleton regulatory protein 1
  cyclin dependent kinase 15
  cyclin dependent kinase like 5
  family with sequence similarity 102 member A
  FCF1 rRNA-processing protein
  G-patch domain containing 2 like
  leucyl-tRNA synthetase 1
  plexin domain containing 2
  serine protease 1
  taste 2 receptor member 8
  TBC1 domain family member 22B
  tetratricopeptide repeat domain 5
  TOX high mobility group box family member 4
  zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.