PRKAG3, protein kinase AMP-activated non-catalytic subunit gamma 3

PRKAG3, protein kinase AMP-activated non-catalytic subunit gamma 3

• The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]

• Gene Synonyms (5'-AMP-activated protein kinase subunit gamma-3, 5'-AMP-activated protein kinase, gamma-3 subunit, AMPK gamma-3 chain, AMPK gamma3, AMPK subunit gamma-3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, AMPKG3,)
• NCBI Gene ID: 53632
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R426
  UNIPROT ID#>>Q9UGI9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase AMP-activated non-catalytic subunit gamma 3 interacts with:

• keratin associated protein 19-5

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