NANS, N-acetylneuraminate synthase

NANS, N-acetylneuraminate synthase

• This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

• Gene Synonyms (sialic acid synthase, N-acetylneuraminate-9-phosphate synthase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid synthase, epididymis secretory protein Li 100, sialic acid phosphate synthase, HEL-S-100, SAS, SEMDCG, SEMDG,)
• NCBI Gene ID: 54187
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NR45
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

N-acetylneuraminate synthase interacts with:

• autophagy related 3
  carnosine dipeptidase 2
  DET1 and DDB1 associated 1
  fumarylacetoacetate hydrolase domain containing 1
  NAD(P)HX dehydratase
  protein phosphatase 4 regulatory subunit 3B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.