TREM2, triggering receptor expressed on myeloid cells 2

TREM2, triggering receptor expressed on myeloid cells 2

• This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

• Gene Synonyms (triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2a, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c,)
• NCBI Gene ID: 54209
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5TCX1
  UNIPROT ID#>>Q9NZC2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

triggering receptor expressed on myeloid cells 2 interacts with:

• neuritin 1 like
  unc-5 netrin receptor B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.