MAGEL2, MAGE family member L2

MAGEL2, MAGE family member L2

• Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]

• Gene Synonyms (MAGE-like protein 2, melanoma antigen family L2, necdin-like protein 1, protein nM15, NDNL1, PWLS, SHFYNG, nM15,)
• NCBI Gene ID: 54551
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJ55
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAGE family member L2 interacts with:

• polycomb group ring finger 6
  VPS35 retromer complex component

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.