PGPEP1, pyroglutamyl-peptidase I

PGPEP1, pyroglutamyl-peptidase I

• The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

• Gene Synonyms (pyroglutamyl-peptidase 1, 5-oxoprolyl-peptidase, pGlu-peptidase I, pyroglutamyl aminopeptidase I, pyrrolidone-carboxylate peptidase, PAP-I, PGI, PGP, PGP-I, PGPI, Pcp,)
• NCBI Gene ID: 54858
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NXJ5
  UNIPROT ID#>>U3KQ24
  UNIPROT ID#>>S4R2Y9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyroglutamyl-peptidase I interacts with:

• N-terminal glutamine amidase 1
  selenoprotein O
  tripartite motif containing 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.