NEIL3, nei like DNA glycosylase 3

NEIL3, nei like DNA glycosylase 3

• NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, endonuclease 8-like 3, DNA glycosylase FPG2, DNA glycosylase hFPG2, DNA glycosylase/AP lyase Neil3, endonuclease VIII-like 3, nei endonuclease VIII-like 3, nei-like protein 3, zinc finger, GRF-type containing 3,)
• NCBI Gene ID: 55247
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TAT5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nei like DNA glycosylase 3 interacts with:

• 5-hydroxymethylcytosine binding, ES cell specific
  CDKN2A interacting protein
  ENY2 transcription and export complex 2 subunit
  pre-mRNA processing factor 40 homolog A
  RNA binding motif protein 25
  round spermatid basic protein 1 like

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.