PIDD1, p53-induced death domain protein 1

PIDD1, p53-induced death domain protein 1

• The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

• Gene Synonyms (LRDD, PIDD, p53-induced death domain-containing protein 1, leucine-rich repeat and death domain-containing protein, leucine-rich repeats and death domain containing, p53-induced protein with a death domain,)
• NCBI Gene ID: 55367
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HB75
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

p53-induced death domain protein 1 interacts with:

• ring finger protein 123
  RNA polymerase II associated protein 3

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