FRMD4A, FERM domain containing 4A

FRMD4A, FERM domain containing 4A

• This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (CCAFCA, FRMD4, bA295P9.4, FERM domain-containing protein 4A, FERM domain containing 4,)
• NCBI Gene ID: 55691
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NW91
  UNIPROT ID#>>Q9P2Q2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FERM domain containing 4A interacts with:

• WD repeat domain 83

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.