VPS11, VPS11 core subunit of CORVET and HOPS complexes

VPS11, VPS11 core subunit of CORVET and HOPS complexes

• Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Gene Synonyms (END1, HLD12, PEP5, RNF108, hVPS11, vacuolar protein sorting-associated protein 11 homolog, RING finger protein 108, VPS11, CORVET/HOPS core subunit, vacuolar protein sorting 11 homolog,)
• NCBI Gene ID: 55823
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H270
  UNIPROT ID#>>B7Z879
  UNIPROT ID#>>A0A087WXL6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

VPS11 core subunit of CORVET and HOPS complexes interacts with:

• base methyltransferase of 25S rRNA 2 homolog
  calmodulin regulated spectrin associated protein family member 3
  isochorismatase domain containing 2
  keratin associated protein 10-3
  keratin associated protein 10-8
  leucine rich repeat and sterile alpha motif containing 1
  Rab interacting lysosomal protein
  RAN binding protein 17
  ring finger protein 166
  transmembrane protein 266
  ubiquitin conjugating enzyme E2 U
  VPS16 core subunit of CORVET and HOPS complexes
  VPS18 core subunit of CORVET and HOPS complexes
  VPS33A core subunit of CORVET and HOPS complexes
  VPS41 HOPS complex subunit
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.