- Gene Overview
- Interaction Network
- Sequence Verification
SELENOS, selenoprotein S
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This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
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Gene Synonyms (AD-015, ADO15, SBBI8, SELS, SEPS1, VIMP, selenoprotein S, VCP interacting membrane selenoprotein, VCP-interacting membrane protein, tanis, valosin-containing protein-interacting membrane protein,)
- NCBI Gene ID:
55829
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q9BQE4
UNIPROT ID#>>Q6GYA4
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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selenoprotein S interacts with:
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