MAPK11, mitogen-activated protein kinase 11

MAPK11, mitogen-activated protein kinase 11

• This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

• Gene Synonyms (mitogen-activated protein kinase 11, MAP kinase 11, MAP kinase p38 beta, mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, stress-activated protein kinase-2, stress-activated protein kinase-2b, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta,)
• NCBI Gene ID: 5600
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15759
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase 11 interacts with:

• BAG cochaperone 3
  chromosome 9 open reading frame 78
  coiled-coil domain containing 8
  copine 6
  cullin 7
  dual specificity phosphatase 10
  dual specificity phosphatase 16
  eukaryotic elongation factor 2 kinase
  histone deacetylase 3
  HtrA serine peptidase 2
  MAPK activated protein kinase 2
  MAPK activated protein kinase 3
  MAPK activated protein kinase 5
  MAPK interacting serine/threonine kinase 1
  NADPH oxidase activator 1
  obscurin like cytoskeletal adaptor 1
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine phosphatase non-receptor type 5
  protein tyrosine phosphatase non-receptor type 7
  protein tyrosine phosphatase receptor type R
  Rho GTPase activating protein 12
  ribosomal protein S6 kinase A5
  suppressor of cytokine signaling 3
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  valyl-tRNA synthetase 1
  zinc finger HIT-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.