PROP1, PROP paired-like homeobox 1

PROP1, PROP paired-like homeobox 1

• This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]

• Gene Synonyms (homeobox protein prophet of Pit-1, pituitary-specific homeodomain factor, prophet of Pit1, paired-like homeodomain transcription factor, CPHD2, PROP-1,)
• NCBI Gene ID: 5626
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0G2JQ02
  UNIPROT ID#>>O75360
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PROP paired-like homeobox 1 interacts with:

• abhydrolase domain containing 11
  basic leucine zipper ATF-like transcription factor 2
  chromosome 1 open reading frame 94
  chromosome 11 open reading frame 1
  chromosome 19 open reading frame 54
  chromosome 6 open reading frame 15
  chromosome 9 open reading frame 24
  cysteine rich tail 1
  cytochrome c oxidase subunit 6B2
  DAZ associated protein 2
  EGF containing fibulin extracellular matrix protein 2
  family with sequence similarity 166 member A
  family with sequence similarity 168 member A
  haloacid dehalogenase like hydrolase domain containing 3
  HESX homeobox 1
  integrator complex subunit 11
  keratin associated protein 13-1
  keratin associated protein 19-1
  keratin associated protein 19-6
  keratin associated protein 19-7
  keratin associated protein 6-3
  keratin associated protein 8-1
  KH domain containing 1
  MAGE family member D1
  methyltransferase like 15
  methyltransferase like 27
  nuclear receptor subfamily 1 group D member 2
  oligodendrocyte transcription factor 3
  oxoeicosanoid receptor 1
  pleckstrin homology domain containing B2
  POU class 6 homeobox 2
  prolyl 4-hydroxylase subunit alpha 3
  proteasome 20S subunit beta 4
  proteasome subunit beta 11
  ring finger protein 144B
  ring finger protein 4
  single-strand-selective monofunctional uracil-DNA glycosylase 1
  small ubiquitin like modifier 1
  T-box transcription factor 22
  tektin 4
  tektin 5
  terminal nucleotidyltransferase 5B
  TLE family member 1, transcriptional corepressor
  transmembrane protein 42
  tripartite motif containing 42
  tubulointerstitial nephritis antigen like 1
  ubiquitin conjugating enzyme E2 I
  UFM1 specific peptidase 1 (inactive)
  zinc finger protein 503

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.