PROS1, protein S

PROS1, protein S

• This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

• Gene Synonyms (vitamin K-dependent protein S, protein S (alpha), protein Sa, vitamin K-dependent plasma protein S, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6,)
• NCBI Gene ID: 5627
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07225
  UNIPROT ID#>>A0A0S2Z4K3
  UNIPROT ID#>>A0A0S2Z4L3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein S interacts with:

• F-box protein 6
  lysozyme like 2
  TANK binding kinase 1
  tectonic family member 2
  TYRO3 protein tyrosine kinase
  zona pellucida binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.