TRIB3, tribbles pseudokinase 3

TRIB3, tribbles pseudokinase 3

• The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles homolog 3, TRB-3, neuronal cell death inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, p65-interacting inhibitor of NF-kappaB,)
• NCBI Gene ID: 57761
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DMM9
  UNIPROT ID#>>Q96RU7
  UNIPROT ID#>>J3KR25
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tribbles pseudokinase 3 interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3A
  armadillo repeat containing 7
  cancer/testis antigen 1A
  chromosome 22 open reading frame 39
  COP1 E3 ubiquitin ligase
  deltex E3 ubiquitin ligase 2
  developmental pluripotency associated 3
  FA core complex associated protein 20
  FAM161 centrosomal protein A
  GLIS family zinc finger 3
  glutamine amidotransferase like class 1 domain containing 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  INO80 complex subunit B
  iroquois homeobox 6
  kelch like family member 38
  keratin 26
  leukocyte receptor cluster member 1
  mitotic spindle positioning
  par-6 family cell polarity regulator beta
  PBX/knotted 1 homeobox 2
  proline rich 19
  protein phosphatase 1 regulatory subunit 32
  RNA binding motif protein 48
  serine/threonine kinase 40
  sodium channel modifier 1
  stabilizer of axonemal microtubules 1
  sterile alpha motif domain containing 11
  tektin 3
  tektin 4
  tetratricopeptide repeat domain 23
  ubiquitin domain containing 2
  UTP23 small subunit processome component
  zinc finger protein 417
  zinc finger protein 587

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.