ELAC2, elaC ribonuclease Z 2

ELAC2, elaC ribonuclease Z 2

• The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

• Gene Synonyms (zinc phosphodiesterase ELAC protein 2, RNase Z 2, elaC homolog 2, elaC homolog protein 2, elaC-like protein 2, heredity prostate cancer protein 2, putative prostate cancer susceptibility protein HPC2/ELAC2, ribonuclease Z 2, tRNA 3 endonuclease 2, tRNase Z (long form), tRNase Z 2, COXPD17, ELC2, HPC2,)
• NCBI Gene ID: 60528
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5M8
  UNIPROT ID#>>Q9BQ52
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

elaC ribonuclease Z 2 interacts with:

• activating signal cointegrator 1 complex subunit 2
  BCL2-associated athanogene 2
  calcium/calmodulin dependent protein kinase kinase 1
  centrosomal protein 19
  mitochondrial ribosomal protein L21
  mitochondrial rRNA methyltransferase 1
  ribosomal protein L35
  ring finger protein 123

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.