GUF1, GUF1 homolog, GTPase

GUF1, GUF1 homolog, GTPase

• This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

• Gene Synonyms (translation factor GUF1, mitochondrial, GTP-binding protein GUF1 homolog, GTPase of unknown function 1, elongation factor 4 homolog, ribosomal back-translocase, EF-4, EF4, EIEE40,)
• NCBI Gene ID: 60558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R9T3
  UNIPROT ID#>>Q8N442
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GUF1 homolog, GTPase interacts with:

• family with sequence similarity 174 member A
  mitochondrial rRNA methyltransferase 1
  TSPY like 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.