ROBO2, roundabout guidance receptor 2

ROBO2, roundabout guidance receptor 2

• The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Gene Synonyms (roundabout homolog 2, roundabout, axon guidance receptor, homolog 2, SAX3,)
• NCBI Gene ID: 6092
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HCK4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

roundabout guidance receptor 2 interacts with:

• centromere protein U
  centrosomal protein 72
  Fas associated via death domain
  G protein-coupled receptor 152
  kinesin family member 1C
  methyltransferase like 3
  MYC binding protein 2
  nuclear receptor subfamily 1 group H member 2
  olfactomedin 2
  par-6 family cell polarity regulator beta
  protein kinase D2
  protein phosphatase 1 regulatory inhibitor subunit 1B
  retinol dehydrogenase 11
  ribosomal protein S6 kinase A5
  slit guidance ligand 2
  slit guidance ligand 3
  structure specific recognition protein 1
  transmembrane protein 109
  transmembrane protein 237
  transmembrane protein 248
  tripartite motif containing 13
  ubiquilin 4
  VAMP associated protein A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.