SCN8A, sodium voltage-gated channel alpha subunit 8

SCN8A, sodium voltage-gated channel alpha subunit 8

• This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

• Gene Synonyms (sodium channel protein type 8 subunit alpha, hNa6/Scn8a voltage-gated sodium channel, sodium channel, voltage gated, type VIII, alpha subunit, voltage-gated sodium channel subunit alpha Nav1.6, voltage-gated sodium channel type VIII alpha protein, BFIS5, CERIII, CIAT, EIEE13, MED, MYOCL2, NaCh6, Nav1.6, PN4,)
• NCBI Gene ID: 6334
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6B4S4
  UNIPROT ID#>>Q9UQD0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sodium voltage-gated channel alpha subunit 8 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  ring finger protein 123

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.