XYLT2, xylosyltransferase 2

XYLT2, xylosyltransferase 2

• The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

• Gene Synonyms (xylosyltransferase 2, UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, peptide O-xylosyltransferase 1, protein xylosyltransferase 2, xylosyltransferase II, PXYLT2, SOS, XT-II, XT2, xylT-II,)
• NCBI Gene ID: 64132
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H1B5
  UNIPROT ID#>>B4DT06
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

xylosyltransferase 2 interacts with:

• LY6/PLAUR domain containing 4
  protein O-mannose kinase
  pyrin and HIN domain family member 1
  reticulophagy regulator family member 3
  TBC1 domain family member 32

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.