MMP25, matrix metallopeptidase 25

MMP25, matrix metallopeptidase 25

• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

• Gene Synonyms (matrix metalloproteinase-25, leukolysin, matrix metallopeptidase-like 1, matrix metalloproteinase 20, matrix metalloproteinase-like 1, membrane-type 6 matrix metalloproteinase, membrane-type matrix metalloproteinase 6, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6,)
• NCBI Gene ID: 64386
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NPA2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

matrix metallopeptidase 25 interacts with:

• cytochrome P450 family 4 subfamily F member 12

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