SLC6A4, solute carrier family 6 member 4

SLC6A4, solute carrier family 6 member 4

• This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]

• Gene Synonyms (sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT,)
• NCBI Gene ID: 6532
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2R7Y7
  UNIPROT ID#>>P31645
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 6 member 4 interacts with:

• calmodulin 1
  prostaglandin E synthase 3
  protein phosphatase 3, catalytic subunit, alpha isoform
  secretory carrier membrane protein 2
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  syntaxin 1A
  synuclein alpha
  synuclein gamma
  vesicle associated membrane protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.