SLPI, secretory leukocyte peptidase inhibitor

SLPI, secretory leukocyte peptidase inhibitor

• This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

• Gene Synonyms (antileukoproteinase, HUSI-1, WAP four-disulfide core domain protein 4, mucus proteinase inhibitor, protease inhibitor WAP4, secretory leukocyte protease inhibitor (antileukoproteinase), seminal proteinase inhibitor, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4,)
• NCBI Gene ID: 6590
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P03973
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

secretory leukocyte peptidase inhibitor interacts with:

• calcium and integrin binding family member 3
  calneuron 1
  family with sequence similarity 9 member B
  linker for activation of T cells
  makorin ring finger protein 3
  MICOS10-NBL1 readthrough
  mitogen-activated protein kinase 8 interacting protein 2
  N-terminal glutamine amidase 1
  PIH1 domain containing 2
  ring finger protein 123
  small glutamine rich tetratricopeptide repeat containing beta
  small integral membrane protein 14
  ubiquilin 1
  ubiquilin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.