SPRR2E, small proline rich protein 2E

SPRR2E, small proline rich protein 2E

• This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

• Gene Synonyms (small proline-rich protein 2E, SPR-2E, SPR-II, small proline-rich protein II,)
• NCBI Gene ID: 6704
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22531
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

small proline rich protein 2E interacts with:

• A kinase (PRKA) anchor protein (gravin) 12
  cyclin-dependent kinase 1
  Ras association domain family member 10
  Ras association domain family member 2
  Ras association domain family member 9
  reticulophagy regulator family member 2
  suppressor of variegation 3-9 homolog 2
  thioesterase superfamily member 6
  zinc finger and BTB domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.