DENND2B, DENN domain containing 2B

DENND2B, DENN domain containing 2B

• This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DENN domain-containing protein 2B, DENN/MADD domain containing 2B, heLa tumor suppression 1, suppression of tumorigenicity 5 protein, HTS1, ST5, p126,)
• NCBI Gene ID: 6764
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78524
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DENN domain containing 2B interacts with:

• actin, beta
  anillin actin binding protein
  calmodulin-like 3
  coronin, actin binding protein 1C
  flotillin 1
  myosin IC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.