TFPI, tissue factor pathway inhibitor

TFPI, tissue factor pathway inhibitor

• This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

• Gene Synonyms (tissue factor pathway inhibitor, anti-convertin, extrinsic pathway inhibitor, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), EPI, LACI, TFI, TFPI1,)
• NCBI Gene ID: 7035
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P10646
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tissue factor pathway inhibitor interacts with:

• BCAS2 pre-mRNA processing factor
  potassium voltage-gated channel interacting protein 4
  serine and arginine rich splicing factor 11
  Sin3A associated protein 18
  SMU1 DNA replication regulator and spliceosomal factor
  splicing factor 3b subunit 1
  thrombospondin 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.