RNF103, ring finger protein 103

RNF103, ring finger protein 103

• The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF103, RING-type E3 ubiquitin transferase RNF103, zinc finger protein 103 homolog, zinc finger protein expressed in cerebellum, HKF-1, KF-1, KF1, ZFP-103, ZFP103,)
• NCBI Gene ID: 7844
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00237
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 103 interacts with:

• derlin 1
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 W
  ubiquitin conjugating enzyme E2 Z

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.