FTO, FTO alpha-ketoglutarate dependent dioxygenase

FTO, FTO alpha-ketoglutarate dependent dioxygenase

• This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

• Gene Synonyms (alpha-ketoglutarate-dependent dioxygenase FTO, AlkB homolog 9, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, fat mass and obesity associated, fat mass and obesity-associated protein, m6A(m)-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO, ALKBH9, BMIQ14, GDFD,)
• NCBI Gene ID: 79068
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99770
  UNIPROT ID#>>B3KU60
  UNIPROT ID#>>A0A1B0GTC5
  UNIPROT ID#>>Q9C0B1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FTO alpha-ketoglutarate dependent dioxygenase interacts with:

• coiled-coil domain containing 57
  deltex E3 ubiquitin ligase 2
  fibronectin type III and SPRY domain containing 1
  kelch like family member 38
  MORN repeat containing 3
  olfactory receptor family 5 subfamily F member 1
  PR/SET domain 6
  SET binding factor 2
  tRNA-yW synthesizing protein 3 homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.