PANK2, pantothenate kinase 2

PANK2, pantothenate kinase 2

• This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (pantothenate kinase 2, mitochondrial, Hallervorden-Spatz syndrome, pantothenate kinase-associated neurodegeneration, pantothenic acid kinase 2, C20orf48, HARP, HSS, NBIA1, PKAN,)
• NCBI Gene ID: 80025
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D3DVZ1
  UNIPROT ID#>>Q9BZ23
  UNIPROT ID#>>Q6P1K9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pantothenate kinase 2 interacts with:

• DDB1 and CUL4 associated factor 15
  DEAH-box helicase 36
  glutamine rich 2
  spermidine/spermine N1-acetyltransferase family member 2
  zinc finger protein 526

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.